Pyrrolidine derivatives

ABSTRACT

Pyrrolidine muscarinic receptor antagonists, particularly useful in the treatment of irritable bowel syndrome, of the formula:- &lt;CHEM&gt;  and their pharmaceutically acceptable salts,  wherein Y is a direct link, -CH2-, -(CH2)2-, -CH2O- or -CH2S-;  R is -CN or -CONH2;  and R&lt;1&gt; is a group of the formula:- &lt;CHEM&gt;  where X and X&lt;1&gt; are each independently O or CH2;  m is 1, 2 or 3; and &#34;Het&#34; is pyridyl, pyrazinyl or thienyl. u



